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Several antioxidant factors, including ascorbic acid, cysteine, GSH, tyrosine and uric acid, can be found in the ocular tear film and may protect from oxidative stress under physiologic conditions [12,49]

Endothelin-1 (ET-1), a well-known vasoconstrictor, has been shown to increase in POAG patients [415,416,417]

The metabolic heterogeneity of diverse tumor types, varied clinical stages, distinct cell populations within the TME may be one of the factors contributing to the poor efficacy of metabolic-targeted drugs

In vitro, isolated PSCs in the high-glucose group expressed higher levels of -SMA and collagen I and had a higher cell proliferation rate

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